Heat shock response and insulin-associated neurodegeneration
نویسندگان
چکیده
منابع مشابه
Heat shock response and insulin-associated neurodegeneration.
Dysfunctional insulin and insulin-like growth factor-I (IGF-I) signaling contributes to the pathological progression of diabetes, diabetic peripheral neuropathy (DPN), Alzheimer's (AD), Parkinson's (PD) and Huntington's diseases (HD). Despite their prevalence, there are limited therapeutic options available for the treatment of these neurodegenerative disorders. Therefore, establishing a link b...
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the phenomenon of " hormesis ". Exposure of organisms to mild stress fortifies them against subsequent, more severe insults. Yet, the relevant molecular mechanisms remain poorly understood. Although heat stroke is often fatal and survivors may suffer permanent neurologic damage, the mechanisms underlying heat stroke-induced cell and tissue injury remain elusive. To gain insight, we employed the...
متن کاملThe heat-shock response.
PERSPECTIVES AND SUMMARY .............................................................. 1151 CHARACTERIZATION OF THE RESPONSE .................................................. 1153 Comparison: Different Organisms and Stages of Development ........................... 1153 The Proteins Induced by Heat .................................................................. 1155 RNAs Induced by Heat .....
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In cells, hyperthermia induces synthesis of heat-shock proteins and the acquisition of thermotolerance. Thermotolerant cells are resistant to subsequent oxidative stress. In this study, heat-shocked hearts were examined for evidence of protection during ischemia and reperfusion. Rats were exposed to 15 minutes of 42 degrees C hyperthermia. Twenty-four hours later their hearts were isolated and ...
متن کاملThermodynamics of heat-shock response.
Production of heat-shock proteins is induced when a living cell is exposed to a rise in temperature. The heat-shock response of protein DnaK synthesis in E.coli for temperature shifts T-->T+DeltaT and T-->T-DeltaT is measured as a function of the initial temperature T. We observe a reversed heat shock at low T. The magnitude of the shock increases when one increases the distance to the temperat...
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2012
ISSN: 0165-6147
DOI: 10.1016/j.tips.2011.11.001